Acanthopanax, Wu Jia Pi ไบ”ๅŠ ็šฎ

Wu Jia Pi (TCM)

Eleutherococcus senticosus
Komarov (Komorov), V.L., Flora of the U.S.S.R., vol. 16 (?)

Eleutherococcus henryi
Curtis’s botanical magazine, vol. 136 (1801)

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Acanthopanax leucorrhizus (called ‘Narrow-leaf Wu Jia‘ in China)
Curtisโ€™s Botanical Magazine, 1915

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Botanical name:

Acanthopanax spp. (syn. Eleutherococcus spp.)
  1. A. gracilistylus
  2. A. sessilifforus

Parts used:

Root-bark

Temperature & Taste:

Warm, dry. Pungent, Bitter

Classification:

D. Clear Wind and Damp

Uses:

  1. Clears Wind-Damp, Strengthens Bones and Joints:
    • Joint pain; Spasms in the limbs or lower backRheumatic or Rheumatoid Arthralgia (Chinese Pharmacopoeia)Lower Back pain from Kidney weakness or old agepain associated with with Kidney and Liver weakness

  2. Clears Damp, Promotes Urine:
    • Edema
    • Urinary difficulty
    • Cold swelling and pain in the legs

  3. Benefit the Liver and Kidney:
    • deficiency Kidney and Liver Yin in the Elderly, especially with Back pain, lower body weakness, frailty
    • Slow Development, Retardation, or Failure to Thrive in Children

Dose:

Decoction: 4โ€“12 grams
Powder: 1โ€“4 grams

Comment:

Acanthopanax Wu Jia Pi is closely related to Siberian Ginseng (A. senticosus). Wu Jia Pi is more effective for chronic bone and joint disease with deficiency, while Siberian Ginseng has Qi tonic properties. Siberian Ginseng is listed as an equivalent plant in various Chinese texts (including Encyclopedia of Traditional Chinese Medicine, JiaJu Zhou et al.)

Substitute:

 … available in PRO version

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Main Combinations:

  1. Arthritis, Joint Pain:
    1. i. Chronic joint pain, Acanthopanax Wu Jia Pi  … available in PRO version
    2. ii. Aches and pain of the lower back, hips and legs, Acanthopanax Wu Jia Pi with  … available in PRO version
    3. iii. Cold-damp pain, cold pain in the lower back and legs, Acanthopanax Wu Jia Pi,  … available in PRO version
    4. iv. Acanthopanax Wu Jia Pi with  … available in PRO version
    5. v. Rheumatism, Paralysis, Acanthopanax Wu Jia Pi with  … available in PRO version
  2. Lower Back  and Knee Pain and weakness:i. Acanthopanax Wu Jia Pi with  … available in PRO version
    1. ii. Acanthopanax Wu Jia Pi with  … available in PRO version
    2. iii. Lower Back and Knee pain and weakness, barely able to walk, Acanthopanax Wu Jia Pi with  … available in PRO version
  3. Edema, Acanthopanax Wu Jia Pi with  … available in PRO version
  4. Beriberi, swollen skin, and joint pain, Acanthopanax Wu Jia Pi with  … available in PRO version
  5. Delayed Walking in a child of 4 or 5 years age, Acanthopanax Wu Jia Pi with  … available in PRO version

Cautions:

Generally safe

Main Preparations used:

GENERAL / REVIEW
โ€“Acanthopanax henryi: Review of Botany, Phytochemistry and Pharmacology.
โ€“Advances in the Extraction, Purification, Structural Characteristics and Biological Activities of Eleutherococcus senticosus Polysaccharides: A Promising Medicinal and Edible Resource With Development Value
ANTIOXIDANT
โ€“The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum
โ€“In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species
ANTI-INFLAMMATORY
โ€“A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
IMMUNOSTIMULANT
โ€“Immunostimulating Effects of Extract of Acanthopanax sessiliflorus
ANTI-HYPERTENSIVE
โ€“Antihypertensive Effect of Ethanolic Extract from Acanthopanax sessiliflorus Fruits and Quality Control of Active Compounds
ARTHRITIS
โ€“Prophylactic and Therapeutic Effects of Acanthopanax senticosus Harms Extract on Murine Collagen-induced Arthritis
OSTEOPOROSIS
โ€“Eleutherococcus sessiliflorus Inhibits Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)-Induced Osteoclast Differentiation and Prevents Ovariectomy (OVX)-Induced Bone Loss
โ€“Anti-Osteoporosis Effects of the Eleutherococcus senticosus, Achyranthes japonica, and Atractylodes japonica Mixed Extract Fermented with Nuruk
โ€“Preventive Effects of Eleutherococcus senticosus Bark Extract in OVX-Induced Osteoporosis in Rats
ADAPTOGENIC
โ€“Acanthopanax sessiliflorus stem confers increased resistance to environmental stresses and lifespan extension in Caenorhabditis elegans
โ€“Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)
ANTI-FATIGUE
โ€“Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus
IMMUNOMODULATORY
–A review on the immunomodulatory activity of Acanthopanax senticosus and its active components
โ€“Acanthopanax koreanum Nakai modulates the immune response by inhibiting TLR 4-dependent cytokine production in rat model of endotoxic shock
โ€“Immunomodulatory effect of Acanthopanax senticosus polysaccharide on immunosuppressed chickens
NEUROPROTECTIVE
โ€“Transcriptomic and Metabolomic Profiling Reveals the Protective Effect of Acanthopanax senticosus (Rupr. & Maxim.) Harms Combined With Gastrodia elata Blume on Cerebral Ischemia-Reperfusion Injury
ANXIETY
โ€“Anxiolytic Effects of Acanthopanax senticosus HARMS Occur via Regulation of Autonomic Function and Activate Hippocampal BDNFโ€“TrkB Signaling
ENHANCES COGNITION
โ€“Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults
MEMORY
โ€“Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain
โ€“In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species
ALZHEIMER’S DISEASE
โ€“Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer’s disease
DIABETES
โ€“Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice
CANCER
–Chinese Medicinal Herb, Acanthopanax gracilistylus, Extract Induces Cell Cycle Arrest of Human Tumor Cells in vitro
โ€“Anti-tumour effects of polysaccharide extracted from Acanthopanax senticosus and cell-mediated immunity
โ€“The cytotoxic nature of Acanthopanax sessiliflorus stem bark extracts in human breast cancer cells
RADIOPROTECTIVE
โ€“The Therapeutic Effect of Acanthopanax senticosus Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters