Bladder Cancer

Bladder Cancer typically occurs in the Urothelial cells of the Bladder but can also form in other areas of the Urinary tract such as the Kidneys and Ureters. There are several types of Bladder Cancer:

Urothelial–most common, forms in the cell lining
Squamous cell–usually associated with chronic inflammation or infection including schistosomiasis infection
Adenocarcinoma–very rare

Primary signs of Bladder Cancer:

Blood in the urine
Frequent or Painful Urination
Back Pain

Risk factors include old age, being male, smoking, family history and a history of bladder infection. Exposure to certain chemicals has also been linked to Bladder cancer. Arsenic, chlorine and aristolchic acid, as well as various paints, dyes and petrochemicals increase risk of bladder cancer.
Typical modern western treatment involves surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy.
In Traditional medicine, Bladder cancer may be classed with Hematuria, or difficult and painful urination. Herbs with proven anti-cancer effect that work on the urinary system can be used. Long-term use of a Kidney tonic such as Liu Wei Di Huang Wan or Zhi Bai Di Huang Wan are beneficial and can be used along with western treatment.

Western Tradition
Simples

Barley
Agrimony
Asparagus root
Plantain seed
Black Nightshade
Pill Millipedes

Yarrow
Couch Grass
Marshmallow root
Sarsaparilla
Winter Cherry

Chinese Classification
Simples

Poria Fu Ling
Phellinus
Scutellaria Bai Zhi Lian
Smilax Tu Fu Ling
Semiaquilaegia Tian Kui

Polyporus Zhu Ling
Plantain seed (Che Qian Zi)
Hedyotis
Solanum nigrum Long Kui

Formulas
Damp-Heat
Long Dan Xie Gan Tang
Xiao Chai Hu Tang
Supportive in chronic or advanced cases
Bu Zhong Yi Qi Tang
Liu Wei Di Huang Wan
Zhi Bai Di Huang Wan

Special Formula
Proven Combination
Heyotis Bai Hua She She Cao
Scutellaria barbata Bai Zhi Lian
This combination has been shown to inhibit Bladder Cancer. (see here)
Kuan Sin Yin Decoction
Poria Fu Ling
Codonopsis Dang Shen
Licorice
Atractylodes Bai Zhu
Astragalus Huang Qi
Ligustrum Nu Zhen Zi
Pogostemon Huo Xiang
This has been used in China for Bladder Cancer (see here)
Qi Ci San Ling Decoction
Astragalus Huang Qi 10 qian
Sagittaria sagittifolia Ci Gu 10 qian
Polyporus Zhu Ling      5 qian
Poria Fu Ling 5 qian
Paeonia Bai Shao 5 qian
Zedoary (E Zhu) 5 qian
Cinnamon twigs (Gui Zhi) 3 qian
Licorice (Gan Cao) 2 qian
Rehmannia Shu Di Huang   5 qian
Smilax Tu Fu Ling   5 qian
This has been studied and proven to promote Apopotosis in Bladder Cancer cells (see here)
Zhu Ling Ji Sheng Decoction
Astragalus Huang Qi
Polyporus Zhu Ling
Taxillus Sang Ji Sheng
Cremastra Shan Ci Gu
Heyotis Bai Hua She She Cao
This has been studied and found to work via multiple pathways against Bladder Cancer cells.
Formula used successfully in Matastatic
Lung Cancer from Bladder Cancer
Ginseng
Cordyceps militaris
Myrrh
Boswellia
Notoginseng San Qi
Cremastra Shan Ci Gu
Bezoar
Pearl
See case history here.

Extra Info
History
Research
Comment

Aloe vera
–Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer.
Amygdalin (Bitter Almond)
–Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review.
Andrographis
–Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Angelica gigas
–Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds.
Berberine (Barberry, Coptis Huang Lian, Scutellaria Huang Qin, Golden Seal)
–Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p.
Boswellia:
–Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study
–Cancer Chemopreventive Effects of Boswellia sacra Gum Resin Hydrodistillates on Invasive Urothelial Cell Carcinoma: Report of a Cas
–Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity
Black Cohosh
–Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways.
Cannabis
–Systematic review of the potential role of cannabinoids as antiproliferative agents for urological cancers
Hedyotis diffusa
–Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression.
Hypericum
–The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells.
Lycium Gou Qi Zi
–Lycium barbarum polysaccharides inhibit proliferation and migration of bladder cancer cell lines BIU87 by suppressing Pi3K/AKT pathway.
Olibanum
–Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study
–Cancer Chemopreventive Effects of Boswellia sacra Gum Resin Hydrodistillates on Invasive Urothelial Cell Carcinoma: Report of a Cas
–Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity
Paeonia
–The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art.
–Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo.
–Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities.
Paris
–Polyphyllin II inhibits human bladder cancer migration and invasion by regulating EMT-associated factors and MMPs.
–Paris polyphylla ethanol extract induces G2/M arrest and suppresses migration and invasion in bladder cancer.
–Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression.
Polyporus Zhu Ling
–[Inhibitory effect of Chinese herb medicine zhuling on urinary bladder cancer. An experimental and clinical study].
–Homogeneous Polyporus Polysaccharide Inhibit Bladder Cancer by Resetting Tumor-Associated Macrophages Toward M1 Through NF-κB/NLRP3 Signaling.
–Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment.
Pueraria
–Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.
Solanum nigrum
–A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer.
–Solasonine Induces Apoptosis and Inhibits Proliferation of Bladder Cancer Cells by Suppressing NRP1 Expression.
Combinations / Formula
–Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression.
–Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression.
–Effects of Buzhong Yiqi Decoction Combined with THP Bladder Perfusion on Postoperative Efficacy in Patients with Bladder Cancer.