| GENERAL / REVIEW | TESTICULAR PROTECTIVE |
| –The genus Cordyceps: An extensive review of its traditional uses, phytochemistry and pharmacology. | –Cordycepin from Medicinal Fungi Cordyceps militaris Mitigates Inflammaging-Associated Testicular Damage via Regulating NF-κB/MAPKs Signaling in Naturally Aged Rats. |
| –Comparative analysis of the complete mitochondrial genomes of four cordyceps fungi. | –Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway. |
| –Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms. | –Protective Effects of Nucleosides-Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage. |
| –Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes. | –Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats. |
| –Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity. | BENIGN PROSTATIC HYPERTROPHY |
| –Physicochemical, functional and structural properties of the major protein fractions extracted from Cordyceps militaris fruit body. | –Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy. |
| –Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. | PROMOTES FERTILITY |
| –Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety. | –Promotes Male and Female Fertility |
| –Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential. | –[Cordyceps sinensis combined with Jujing Pills for male infertility]. Yang ZX, Chen Y, Xue JG, Huang XF, Chang FJ. |
| –Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure, and bioactivities: A review. | EFFECT ON GUT MICROBIOME |
| –An Evaluation of Common Cordyceps (Ascomycetes) Species Found in Chinese Markets. | –Cordyceps militaris Modulates Intestinal Barrier Function and Gut Microbiota in a Pig Model. |
| –Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris. | –A polysaccharide from natural Cordyceps sinensis regulates the intestinal immunity and gut microbiota in mice with cyclophosphamide-induced intestinal injury. |
| CORDYCEPS CICADAE AS A SUBSTITUTE | –Using Cordyceps militaris extracellular polysaccharides to prevent Pb2+-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota. |
| –Can Cordyceps cicadae be used as an alternative to Cordyceps militaris and Cordyceps sinensis? – A review. | OBESITY |
| –Biological characteristics, bioactive components and antineoplastic properties of sporoderm-broken spores from wild Cordyceps cicadae. | –System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats. |
| ANTI-BACTERIAL | –Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism. |
| –Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity. | NEPHROPROTECTIVE |
| ANTI-VIRAL | –Nephro-protective: improves Kidney function in chronic renal failure, speeds recovery after gentamycin-induced Kidney damage. |
| –Novel Fatty Acid in Cordyceps Suppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways. | –Using Cordyceps militaris extracellular polysaccharides to prevent Pb2+-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota. |
| COVID | –Cordyceps sinensis prevents contrast-induced nephropathy in diabetic rats: its underlying mechanism. |
| –Cordycepin: a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19. | CHRONIC KIDNEY DISEASE |
| ANTI-INFLAMMATORY | –Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris. |
| –Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms. | –Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. |
| –Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma. | –Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway. |
| –Anti-inflammation activity of exopolysaccharides produced by a medicinal fungus Cordyceps sinensis Cs-HK1 in cell and animal models. | –Potential therapeutic effects of Cordyceps cicadae and Paecilomyces cicadae on adenine-induced chronic renal failure in rats and their phytochemical analysis. |
| –Anti-inflammation activity of exopolysaccharides produced by a medicinal fungus Cordyceps sinensis Cs-HK1 in cell and animal models. | METABOLIC DISEASE |
| ANTIOXIDANT | –The potential application of Cordyceps in metabolic-related disorders. |
| –Antioxidant and Immunostimulatory Activities of a Submerged Culture of Cordyceps sinensis Using Spent Coffee. | DIABETES |
| –Structure analysis and antioxidant activity of polysaccharide-iron (III) from Cordyceps militaris mycelia. | –Diabetes: lowers blood sugar, promotes release of insulin, increase cell sensitivity to Insulin. (C. sinesis and C. miliaris) |
| –Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae. | –Mechanism of Cordyceps sinensis and its Extracts in the Treatment of Diabetic Kidney Disease: A Review. |
| –Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro. | –Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet. |
| ALLERGIC RHINITIS | –Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris. |
| –Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma. | –Glucose-lowering and hypolipidemic activities of polysaccharides from Cordyceps taii in streptozotocin-induced diabetic mice. |
| ASTHMA | –Antioxidant and Hypoglycemic Effects of Acidic-Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice. |
| –Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma. | –1H NMR-based metabonomics of the hypoglycemic effect of polysaccharides from Cordyceps militaris on streptozotocin-induced diabetes in mice. |
| –Cordyceps polysaccharide ameliorates airway inflammation in an ovalbumin-induced mouse model of asthma via TGF-β1/Smad signaling pathway. | –Evaluation of the Anti-Diabetic Activity of Polysaccharide from Cordyceps cicadae in Experimental Diabetic Rats. |
| CHRONIC LUNG DISEASE / COPD | DIABETIC NEPHROPATHY |
| –Chronic Lung Disease and COPD have shown improvement. | –Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy. |
| –Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. | –Cordyceps militaris polysaccharides exerted protective effects on diabetic nephropathy in mice via regulation of autophagy. |
| LUNG PROTECTIVE | FIBRINOLYTIC |
| –Protective effect of Cordyceps sinensis extract on lipopolysaccharide-induced acute lung injury in mice. | –Gene cloning, expression and homology modeling of first fibrinolytic enzyme from mushroom (Cordyceps militaris). |
| HYPOXIA | CANCER |
| –Supercritical Carbon Dioxide Extracts of Cordyceps sinensis: Chromatography-based Metabolite Profiling and Protective Efficacy Against Hypobaric Hypoxia. | –Anti-Cancer: against various cell lines including oral, colon, bladder, leukemia, melanoma, breast and prostate. |
| –Discovery of the signal pathways and major bioactive compounds responsible for the anti-hypoxia effect of Chinese cordyceps. | (Medicinal Mushrooms A Clinical Guide – 2nd Ed., Powell, 2014) |
| HEPATOPROTECTIVE | –Cordyceps extract was found more effective than Ping Xiao Capsules in mid-to-advanced stages of various cancers. |
| –Hepato-protective: inhibits hepatic fibrosis, restores liver function after damage including alcohol-induced Liver damage. (C. sinesis and C. miliaris) | –Cordyceps militaris extract induces apoptosis and pyroptosis via caspase-3/PARP/GSDME pathways in A549 cell line. |
| –Using Cordyceps militaris extracellular polysaccharides to prevent Pb2+-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota. | –Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties. |
| –Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice. | –Large-scale isolation and antitumor mechanism evaluation of compounds from the traditional Chinese medicine Cordyceps Militaris. |
| ACUTE LIVER FAILURE | –1H-NMR-Based Metabolic Profiling of Cordyceps militaris to Correlate the Development Process and Anti-Cancer Effect. |
| –Evaluation of the mechanism of cordyceps polysaccharide action on rat acute liver failure. | –The effect of fermentation conditions on the structure and anti-tumor activity of polysaccharides from Cordyceps gunnii. |
| ATHEROSCLEROSIS | –Comparison of Chemical Compositions, Bioactive Ingredients, and In Vitro Antitumor Activity of Four Products of Cordyceps (Ascomycetes) Strains from China. |
| –The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis. | –Effects of Different Temperatures on the Chemical Structure and Antitumor Activities of Polysaccharides from Cordyceps militaris. |
| –The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia. | –Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro. |
| –Integrated bioinformatics analysis of the anti-atherosclerotic mechanisms of the polysaccharide CM1 from Cordyceps militaris. | –Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris. |
| –Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris. | –A novel protein from edible fungi Cordyceps militaris that induces apoptosis. |
| IMMUNOMODULATORY | –Biological characteristics, bioactive components and antineoplastic properties of sporoderm-broken spores from wild Cordyceps cicadae. |
| –Cordyceps militaris Immunomodulatory Protein Promotes the Phagocytic Ability of Macrophages through the TLR4-NF-κB Pathway. | BREAST |
| –Isolation and immune activity of a new acidic Cordyceps militaris exopolysaccharide. | –Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer. |
| –Antioxidant and Immunostimulatory Activities of a Submerged Culture of Cordyceps sinensis Using Spent Coffee. | –Extracts of Cordyceps sinensis inhibit breast cancer growth through promoting M1 macrophage polarization via NF-κB pathway activation. |
| –Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis. | –Radical Scavenging and Antiproliferative Effects of Cordycepin-Rich Ethanol Extract from Brown Rice-Cultivated Cordyceps militaris (Ascomycetes) Mycelium on Breast Cancer Cell Lines. |
| –Cordyceps sinensis aqueous extract regulates the adaptive immunity of mice subjected to 60 Co γ irradiation. | COLORECTAL |
| –Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. | –Virtual Screening for Biomimetic Anti-Cancer Peptides from Cordyceps militaris Putative Pepsinized Peptidome and Validation on Colon Cancer Cell Line. |
| –Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin. | –Cordyceps sinensis polysaccharide inhibits colon cancer cells growth by inducing apoptosis and autophagy flux blockage via mTOR signaling. |
| –Immunomodulatory and Antioxidant Effects of Polysaccharides from the Parasitic Fungus Cordyceps kyushuensis. | GASTRIC |
| –Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley. | –Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress. |
| –Structural characterization and immune-enhancing activity of a novel high-molecular-weight polysaccharide from Cordyceps militaris. | LEUKEMIA |
| –Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. | –Antileukaemic Cell Proliferation and Cytotoxic Activity of Edible Golden Cordyceps (Cordyceps militaris) Extracts. |
| –Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease. | –[Effects of cultivated Cordyceps sinensis on proliferation and apoptosis of human leukemia K562 cells]. |
| ANTOIMMUNE DISEASE | –Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model. |
| –Effect of Cordyceps sinensis on the Treatment of Experimental Autoimmune Encephalomyelitis: A Pilot Study on Mice Model. | LUNG |
| NEUROPROTECTIVE | –Cordyceps acid alleviates lung cancer in nude mice. |
| –Neuroprotective Effects of Cordyceps cicadae (Ascomycetes) Mycelium Extract in the Rat Model of Optic Nerve Crush. | –Cordyceps militaris Exerts Anticancer Effect on Non-Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3. |
| –Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Protects Aβ1-42-Induced Neurologic Damage in C6 Glial Cells. | –The Extract of Cordyceps Militaris Inhibited the Proliferation of Cisplatin-Resistant A549 Lung Cancer Cells by Downregulation of H-Ras. |
| –The protective effect of cordyceps sinensis extract on cerebral ischemic injury via modulating the mitochondrial respiratory chain and inhibiting the mitochondrial apoptotic pathway. | –Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cells through the protein kinase B/glycogen synthase kinase 3β/β-catenin signaling pathway. |
| –Neuroprotective and therapeutic effect of Cordyceps militaris on ischemia-induced neuronal death and cognitive impairments. | ORAL |
| –Neuroprotective Effects of Butanol Fraction of Cordyceps cicadae on Glutamate-Induced Damage in PC12 Cells Involving Oxidative Toxicity. | –Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model. |
| DEPRESSION | Cordyceps militaris Fraction induces apoptosis and G2/M Arrest via c-Jun N-Terminal kinase signaling pathway in oral squamous carcinoma KB Cells. |
| –Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking. | OVARIAN |
| –Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model. | –Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation. |
| INSOMNIA | PROSTATE |
| –Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double- Blind, Randomized, Placebo-Controlled Trial. | –Cordyceps sinensis Promotes the Growth of Prostate Cancer Cells. |
| ALZHEIMER’S DISEASE | SQUAMOUS CELL CARCINOMA |
| –Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Aβ1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation. | –Cordyceps militaris Fraction induces apoptosis and G2/M Arrest via c-Jun N-Terminal kinase signaling pathway in oral squamous carcinoma KB Cells. |
| –Protective role of Cordyceps militaris in Aβ1-42-induced Alzheimer’s disease in vivo. | ANTI-METASTATIC |
| COGNITIVE DECLINE | –Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris. |
| –Neuroprotective and therapeutic effect of Cordyceps militaris on ischemia-induced neuronal death and cognitive impairments. | –Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. |
| –Improvement of Learning and Memory Induced by Cordyceps Polypeptide Treatment and the Underlying Mechanism. | ANTI-ANGIOGENIC |
| ANTI-AGEING | –Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris. |
| –Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea. | CHEMOTHERAPY TOXICITY |
| –Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae. | –Protective Effects of Nucleosides-Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage. |
| VISION DETERIORATION | –Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Mycelia Attenuates Doxorubicin-Induced Oxidative Stress and Upregulates Krebs Cycle Dehydrogenases Activity and ATP Level in Rat Brain. |
| –Protective Effect of a Water-Soluble Carotenoid-Rich Extract of Cordyceps militaris against Light-Evoked Functional Vision Deterioration in Mice. | –Cordyceps cicadae Mycelia Ameliorate Cisplatin-Induced Acute Kidney Injury by Suppressing the TLR4/NF-κB/MAPK and Activating the HO-1/Nrf2 and Sirt-1/AMPK Pathways in Mice. |
| ENHANCES ATHLETIC PERFORMANCE / ENDURANCE | –Polysaccharides obtained from mycelia of Cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy. |
| –Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production. | –Protective effects of polysaccharides from Cordyceps gunnii mycelia against cyclophosphamide-induced immunosuppression to TLR4/TRAF6/NF-κB signalling in BALB/c mice. |
| –Rhodiola/Cordyceps-Based Herbal Supplement Promotes Endurance Training-Improved Body Composition But Not Oxidative Stress and Metabolic Biomarkers: A Preliminary Randomized Controlled Study. | –Effect of fermented Cordyceps sinensis on doxorubicin‑induced cardiotoxicity in rats. |
| ENHANCES GROWTH | ENHANCES RADIOTHERAPY |
| –Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs. | –Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair. |
| IMPROVES MALE SEXUAL PERFORMANCE | ATOPIC DERMATITIS |
| –Improves Male Sexual function, increases Male hormones. (C. sinesis and C. miliaris) | –Anti-atopic dermatitis properties of Cordyceps militaris on TNFα/IFNγ-stimulated HaCaT cells and experimentally induced atopic dermatitis in mice. |
| –A study of the aphrodisiac properties of Cordyceps militaris in streptozotocin-induced diabetic male rats. | COSMETIC |
| –Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. | –The Feasibility of Utilizing Cultured Cordyceps militaris Residues in Cosmetics: Biological Activity Assessment of Their Crude Extracts. |
| | –Protective effects of Cordyceps extract against UVB‑induced damage and prediction of application prospects in the topical administration: An experimental validation and network pharmacology study. |
