Eleutherococcus, Siberian Ginseng, Ci Wu Jia ๅˆบไบ”ๅŠ 

Russian Ginseng, Spiny Acanthopanax, Devil’s Shrub, Eleutherococcus Ginseng
Ci Wu Jia (TCM)

Picture

Eleutherococcus senticosus
Komarov (Komorov), V.L., Flora of the U.S.S.R. (1934-1964)

Picture

Eleutherococcus senticosus
(Photo by Salicyna) (Wikimedia)

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Botanical name:

Eleutherococcus senticosus (syn. Acanthopanax senticosus, Hedera senticosa)

Parts used:

Root, Root-bark or Stem-bark

Temperature & Taste:

Warm, dry. Pungent, slightly Bitter

Classification:

N. Tonic

Uses:

  1. Tonifies Spleen, Increases Qi:
    • fatigue, lethargy
    • poor appetite, digestive weakness
    • Spleen deficiency from overthinking or worry
    • Altitude Sickness
    • enhances Immunity
  2. Warms and Strengthens the Kidneys:
    • weakness of the Lower back and Knees
    • Osteoporosis
    • Failure to Thrive in children, growth retardation
    • Impotence, has been used as an aphrodisiac
    • Diabetes (proven hypoglycemic effect)
  3. Benefits the Heart and Brain, Calms the Spirit:
    • Insomnia, dream-disturbed sleep, nervousness, restlessness
    • Poor concentration, Confusion, mild depression, Fear
    • enhances Memory
    • Heart deficiency
  4. Moves the Blood, Clears the Channels:
    • Cold extremities from poor circulation
    • Blood stasis with fixed pain
    • Vasodilator and circulatory stimulant effect

Dose:

Powder: 600mgโ€“3 grams

Comment:

… available in PRO version

Main Combinations:

  1. Dementia, Alzheimer’s Disease: Siberian Ginseng, … available in PRO version
  2. Chronic Fatigue:
    1. i. Siberian Ginseng with … available in PRO version
    2. ii. Siberian Ginseng with … available in PRO version
  3. Failure to thrive in children, enhance growth, Siberian Ginseng, … available in PRO version
  4. Altitude Sickness:
    1. i. Siberian Ginseng with … available in PRO version
    2. ii. Siberian Ginseng with … available in PRO version
  5. Hydrocephalus: Siberian Ginseng with … available in PRO version
  6. Cold extremities, Siberian Ginseng with … available in PRO version
  7. Osteoarthritis, Siberian Ginseng, … available in PRO version
  8. Lung Cancer: Siberian Ginseng, … available in PRO version
  9. Colorectal Cancer, Siberian Ginseng, … available in PRO version
  10. Prostate Cancer, Siberian Ginseng, … available in PRO version
  11. Kidney / Adrenal deficiency:
    1. i. Siberian Ginseng with … available in PRO version
    2. ii. Siberian Ginseng with … available in PRO version
  12. Prostatitis, Siberian Ginseng with … available in PRO version
  13. Impotence, Aphrodisiac:
    1. i. Siberian Ginseng with … available in PRO version
    2. ii. Siberian Ginseng with … available in PRO version

Major Formulas:

Cautions:

  1. Caution in Heat diseases and Yin deficiency.
  2. Commission E listed high blood pressure as a contraindication.
    Drug Interactions::
  3. Suggested to avoid using with stimulants including caffeine, and antipsychotic medication.
  4. May increase serum digoxin levels.

Main Preparations used:

GENERAL / REVIEW
โ€“The Chemical Characterization of Eleutherococcus senticosus and Ci-wu-jia Tea Using UHPLC-UV-QTOF/MS
ANTI-INFLAMMATORY:
โ€“A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model
ANTIOXIDANT:
โ€“The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum
ADAPTOGEN:
โ€“Adaptogens Stimulate Neuropeptide Y and Hsp72 Expression and Release in Neuroglia Cells
โ€“Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stressโ€”Protective Activity
IMMUNOMODULATORY:
โ€“A review on the immunomodulatory activity of Acanthopanax senticosus and its active components
โ€“Effects of Acanthopanax senticosus Polysaccharide Supplementation on Growth Performance, Immunity, Blood Parameters and Expression of Pro-inflammatory Cytokines Genes in Challenged Weaned Piglets
FATIGUE:
โ€“Effects of Eleutherococcus senticosus Cortex on Recovery from the Forced Swimming Test and Fatty Acid ฮฒ-Oxidation in the Liver and Skeletal Muscle of mice
โ€“Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus
ENHANCES MEMORY / COGNITION:
โ€“Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain
โ€“Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults
ALZHEIMER’S DISEASE:
โ€“Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid ฮ’-Induced Axonal Degeneration in Alzheimerโ€™s Disease
โ€“Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer’s models
โ€“Potential Natural Products for Alzheimerโ€™s Disease: Targeted Search Using the Internal Ribosome Entry Site of Tau and Amyloid-ฮฒ Precursor Protein
ENHANCES BONE GROWTH:
โ€“Effect of HT042, Herbal Formula, on Longitudinal Bone Growth in Spontaneous Dwarf Rats
โ€“Astragalus Extract Mixture HT042 Improves Bone Growth, Mass, and Microarchitecture in Prepubertal Female Rats: A Microcomputed Tomographic Study
โ€“Effects of Eleutherococcus Extract Mixture on Endochondral Bone Formation in Rats

OSTEOARTHRITIS:
โ€“Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study
โ€“Traditional Chinese medicine in patients with osteoarthritis of the knee
OSTEOPOROSIS:
โ€“Preventive Effects of Eleutherococcus senticosus Bark Extract in OVX-Induced Osteoporosis in Rats
DIABETES:
โ€“Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice
ANTI-AGING:
โ€“Current Perspective in the Discovery of Anti-aging Agents from Natural Products
CANCER:
โ€“Anti-tumour effects of polysaccharide extracted from Acanthopanax senticosus and cell-mediated immunity
LUNG CANCER:
โ€“Can Aidi injection alleviate the toxicity and improve the clinical efficacy of radiotherapy in lung cancer?: A meta-analysis of 16 randomized controlled trials following the PRISMA guidelines
โ€“Aidi Injection, a Traditional Chinese Medicine Injection, Could Be Used as an Adjuvant Drug to Improve Quality of Life of Cancer Patients Receiving Chemotherapy: A Propensity Score Matching Analysis
โ€“Can Aidi injection restore cellular immunity and improve clinical efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy? A meta-analysis of 17 randomized controlled trials following the PRISMA guidelines
โ€“Clinical Efficacy and Safety of Aidi Injection Plus Docetaxel-Based Chemotherapy in Advanced Nonsmall Cell Lung Cancer: A Meta-Analysis of 36 Randomized Controlled Trials
โ€“Has aidi injection the attenuation and synergistic efficacy to gemcitabine and cisplatin in non-small cell lung cancer? A meta-analysis of 36 randomized controlled trials
โ€“Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer
โ€“Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients
COLORECTAL CANCER:
โ€“Chinese Herbal Medicine and Fluorouracil-Based Chemotherapy for Colorectal Cancer: A Quality-Adjusted Meta-Analysis of Randomized Controlled Trials
PROSTATE CANCER:
โ€“Prevention of Prostate Tumor Development by Stimulation of Antitumor Immunity Using a Standardized Herbal Extract (Deep Immuneยฎ) in TRAMP Mice