Paeonia suffruticosa, Tree Peony, Mu Dan Pi 牡丹皮

Tree Peony
Mu Dan Pi (TCM)
Shing pad ma ser po ཤིང་པད་མ་སེར་པོ་ (P. delavayi, Tibetan Medicine)

Tree Peony root bark Mu Dan Pi (Adam, 2022)

Members CLICK HERE for the PRO VERSION

Botanical name:

Paeonia suffruticosa

Parts used:

Root-bark

Temperature & Taste:

Cool, dry. Slightly Pungent, Bitter

Classification:

B. Clears Heat, Cools the Blood

Uses:

1. Cools the Blood, Clears Heat:
-Heat that has penetrated the Blood (ie. from Epidemic and Infectious diseases) with Bleeding
-frequent or excessive Menstruation associated with Blood Heat
-‘disperses hidden Fire in the Blood’. (Li Shi Zhen)
-P. delavayi is used the same in Tibetan Medicine
2. Moves the Blood, Clears Stasis:
-Blood stasis causing Amenorrhea and menstrual pain with clotting
-abdominal masses and tumors
-Bruising associated with Injury
-‘disperses hard mass and blood stasis’. (Shen Nong Ben Cao)
-‘helps recovery of the damaged tendons and bones’. (Da Ming)
-‘promotes delivery, expels Placenta’. (Da Ming)
-P. delavayi is used the same in Tibetan Medicine
3. Clears Deficient Heat, Benefits the Yin:
-‘Steaming Bone Disorder’; (see below).
-Yin deficiency with Heat, such as in the Elderly, during Menopause, or the aftermath of chronic or Heat disease.
-Fever at night, or feeling of Heat during the night, especially where there is no sweating
-‘Long-term use makes one happy and able to enjoy a long life’. (Wu Pu)
4. Clears Liver Heat:
-Headache, Dizziness, eye pain, flushing and irritability
-skin diseases related to Heat of the Blood and Liver
-P. delavayi is used the same in Tibetan Medicine
5. Clears Heat, Resists Poison, Drains Pus, Reduces Swelling:
-Acne, Eczema and other skin diseases with redness and inflammation
-useful for abscesses; Lung or Intestinal Abscesses
-topically for firm, non-draining sores

Dose:

Decoction: 6–12 grams
Powder: 500mg–3 grams

Comment:

… available in PRO version
Preparations:
… available in PRO version

Main Combinations:

1. Blood Heat from Heat entering the Blood (Infectious diseases):
i. combine Paeonia Mu Dan Pi with … available in PRO version
ii. with purplish Maculae or Bleeding, Paeonia Mu Dan Pi with … available in PRO version
iii. Erysipelas and Purpuric Rashes, Paeonia Mu Dan Pi with … available in PRO version
2. Deficient Heat with Night Fever, dry mouth, aching Back, … available in PRO version
3. Hectic Fever from Yin deficiency, take Paeonia Mu Dan Pi with … available in PRO version
4. Liver heat with Qi stagnation, add Paeonia Mu Dan Pi … available in PRO version
5. Vomiting of Blood from Heat, Paeonia Mu Dan Pi with … available in PRO version
6. Acne:
i. Paeonia Mu Dan Pi with … available in PRO version
ii. Paeonia Mu Dan Pi with … available in PRO version
iii. Paeonia Mu Dan Pi with … available in PRO version
iv. Paeonia Mu Dan Pi with … available in PRO version
v. Paeonia Mu Dan Pi with … available in PRO version
7. Internal Abscesses:
i. Paeonia Mu Dan Pi with … available in PRO version
ii. Paeonia Mu Dan Pi with … available in PRO version
8. Pain due to Bruising and Blood stasis, Amenorrhea and Dysmenorrhea … available in PRO version
9. Pain and swelling after Trauma, … available in PRO version
10. Menopause, Paeonia Mu Dan Pi with … available in PRO version

Major Formulas:

The following formulas are all based on Liu Wei Di Huang Wan (Rehmannia Six)
Liu Wei Di Huang Wan
Er Long Zuo Ci Wan
Mai Wei Di Huang Wan
Ming Mu Di Huang Wan
Qi Ju Di Huang Wan
Shen Qi Wan
Zhi Bai Di Huang Wan
Other Formulas:
Bu Shen Yi Gan Tang
Da Huang Mu Dan Tang
Dan Zhi Xiao Yao San
Du Qi Wan
Ge Xia Zhu Yu Tang
Geng Nian An Pian
Gui Zhi Fu Ling Wan
Kai Yu Zhong Yu Tang
Mie Di Zhi Yang Tang
Ping Gan Kai Yu Zhi Xue Tang
Qi Zhen San
Qing Hao Bie Jia Tang
Qing Wei San
Qing Wen Bai Du Yin
Shi Hui San
Wen Jing Tang
Xi Jiao Di Huang Tang
Xuan Yu Tong Jing Tang
Yang Yin Qing Fei Tang

Cautions:

1. Not for Cold or Blood deficiency
2. Not used during Pregnancy
3. Not for Excess Menstruation unless there is Heat with Blood stasis.
4. Occasional side effects may include dizziness and mild nausea which usually subside without stopping medication.

GENERAL / REVIEW	MEMORY
–Insight into Seasonal Change of Phytochemicals, Antioxidant, and Anti-Aging Activities of Root Bark of Paeonia suffruticosa (Cortex Moutan) Combined with Multivariate Statistical Analysis.	–Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis.
–Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony).	OSTEOARTHRITIS
–Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeonia suffruticosa Andrew): A Systematic Review.	–Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes.
–[Chemical constituents from seeds of Paeonia suffruticosa].	OBESITY
–[Study on chemical constituents of bark of Paeonia suffruticosa].	–Protection by tree-peony (Paeonia suffruticosa Andr) of obesity in (SLN x C3H/He) F1 obese mice.
–Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol.	–Natural products: a safest approach for obesity.
–Paeonol: pharmacological effects and mechanisms of action.	DIABETES
ANTIBACTERIAL	–Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.
–Chemical constituents, antibacterial activity and mechanism of Paeonia suffruticosa Andr. buds extract against Staphylococcus aureus and Escherichia coli O157:H7.	–Pharmacological investigations of the anti-diabetic effect of Cortex Moutan and its active component paeonol.
–Anti-Helicobacter pylori and antiulcerogenic activities of the root cortex of Paeonia suffruticosa.	DIABETIC NEPHROPATHY
–A new monoterpene glycoside and antibacterial monoterpene glycosides from Paeonia suffruticosa.	–Terpene glycoside component from Moutan Cortex ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-related inflammatory responses.
ANTI-VIRAL	CATARACTS
–Identification of anti-HBV activities in Paeonia suffruticosa Andr. using GRP78 as a drug target on Herbochip®.	–[Protection of polysaccharides-2b from mudan cortex of Paeonia suffruticosa andr on diabetic cataract in rats].
–Inhibitory effect of anti-pyretic and anti-inflammatory herbs on herpes simplex virus replication.	CANCER
–A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs.	–Anti-proliferative and anti-metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells.
ANTI-FUNGAL	–The resveratrol oligomers, cis- and trans-gnetin H, from Paeonia suffruticosa seeds inhibit the growth of several human cancer cell lines.
–Isolation of antifungal compound from Paeonia suffruticosa and its antifungal mechanism.	–The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art.
ANTI-INFLAMMATORY	–Anti-proliferative and anti-metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells.
–Root Bark of Paeonia suffruticosa Extract and Its Component Methyl Gallate Possess Peroxynitrite Scavenging Activity and Anti-inflammatory Properties through NF-κB Inhibition in LPS-treated Mice.	–Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex.
–New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity.	BLADDER
–Screening of bioactive compounds from moutan cortex and their anti-inflammatory activities in rat synoviocytes.	–Cortex Moutan Induces Bladder Cancer Cell Death via Apoptosis and Retards Tumor Growth in Mouse Bladders.
ANTIOXIDANT	BREAST
–Purification and identification of an antioxidative peptide from peony (Paeonia suffruticosa Andr.) seed dreg.	–Probing the Molecular Mechanisms Governing the Oncolytic Activity of Paeonia suffruticosa on Triple-negative Breast Cancer Cells In Vitro.
–Chemical Profile and Antioxidant Activity of the Oil from Peony Seeds (Paeonia suffruticosa Andr.).	–In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D, isolated from Paeonia suffruticosa seeds.
–Antioxidant and antimelanogenic behaviors of Paeonia suffruticosa.	COLORECTAL
ANTI-SEPSIS	–Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE₂ synthesis and COX-2 expression.
–Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa.	–Antitumor effect of extracts from moutan cortex on DLD-1 human colon cancer cells in vitro.
CARDIOVASCULAR DISEASE	GASTRIC
–Biological Activities of Paeonol in Cardiovascular Diseases: A Review.	–Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways.
–Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview.	LIVER
VASCULAR DILATION	–Paeonol induces antitumor effects in hepatocellular carcinoma cells through survivin via the cyclooxygenase-2/prostaglandin E2 signaling pathway.
–Vascular dilation by paeonol–a mechanism study.	–In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells.
ANTITHROMBOTIC / ANTICOAGULANT	LUNG
–Antithrombotic Effects of Paeoniflorin from Paeonia suffruticosa by Selective Inhibition on Shear Stress-Induced Platelet Aggregation.	–In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D, isolated from Paeonia suffruticosa seeds.
–Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa.	MELANOMA
–Antithrombotic Effects of Paeoniflorin from Paeonia suffruticosa by Selective Inhibition on Shear Stress-Induced Platelet Aggregation.	–Depigmentation and inhibition of cell growth of B-16 melanoma cells by compounds isolated from Paeonia suffruticosa callus.
HEPATOPROTECTIVE	ORAL
–Palbinone from Paeonia suffruticosa protects hepatic cells via up-regulation of heme oxygenase-1.	–Effects of ethyl acetate extract of peony (Paeonia suffruticosa) seed coat on the proliferation and apoptosis of oral squamous carcinoma cells through miR-424-3p/STAT3/Survivin pathway.
–Moutan Cortex Protects Hepatocytes against Oxidative Injury through AMP-Activated Protein Kinase Pathway.	OSTEOSARCOMA
LIVER DISEASE	–In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D, isolated from Paeonia suffruticosa seeds.
–Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases-A Mini Review.	PANCREAS
HEPATITIS B	–Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells.
–Identification of anti-HBV activities in Paeonia suffruticosa Andr. using GRP78 as a drug target on Herbochip®.	–Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition.
ACUTE LUNG INJURY	RENAL
–Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats.	–Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway.
CIGARETTE-INDUCED LUNG DAMAGE	–Investigation on the antitumor effects of paeonol against renal cell carcinoma based on network pharmacology and experimental validation.
–Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.	ANTI-METASTATIC
PULMONARY FIBROSIS	–Anti-proliferative and anti-metastasis effects of ten oligostilbenes from the seeds of Paeonia suffruticosa on human cancer cells.
–Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol.	REVERSES CHEMOTHERAPY RESISTANCE
ANTI-ULCER	–Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis.
–Anti-Helicobacter pylori and antiulcerogenic activities of the root cortex of Paeonia suffruticosa.	–Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen.
INFLAMMATORY BOWEL DISEASE	–Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2.
–Evaluations and Mechanistic Interrogation of Natural Products Isolated From Paeonia suffruticosa for the Treatment of Inflammatory Bowel Disease.	CHEMOTHERAPY TOXICITY
NEUROPROTECTIVE	–Root bark extracts of Juncus effusus and Paeonia suffruticosa protect salivary gland acinar cells from apoptotic cell death induced by cis-platinum (II) diammine dichloride.
–Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein.	–Screening of herbal medicines for the recovery of cisplatin-induced nephrotoxicity.
–Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson’s disease.	COSMETIC
–Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice.	–Biological screening of 100 plant extracts for cosmetic use (II): anti-oxidative activity and free radical scavenging activity.
ALZHEIMER’S DISEASE	SKIN WHITENING
–Enzyme-assisted Solvent Extraction of High-yield Paeonia suffruticosa Andr. Seed Oil and Fatty Acid Composition and Anti-Alzheimer’s Disease Activity.	–Safety and efficacy of tyrosinase inhibition of Paeonia suffruticosa Andrews extracts on human melanoma cells.
–A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer’s amyloid beta proteins in vitro and in vivo.	–trans-Caffeic acid stearyl ester from Paeonia suffruticosa inhibits melanin synthesis by cAMP-mediating down-regulation of α-melanocyte-stimulating hormone-stimulated melanogenesis signaling pathway in B16 cells.
–Enzyme-assisted Solvent Extraction of High-yield Paeonia suffruticosa Andr. Seed Oil and Fatty Acid Composition and Anti-Alzheimer’s Disease Activity.	–Antioxidant and antimelanogenic behaviors of Paeonia suffruticosa.
–Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer’s disease.	–Tyrosinase inhibitors isolated from the roots of Paeonia suffruticosa.
PARKINSON’S DISEASE	SKIN PHOTOAGEING
–Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson’s disease.	–Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway.
–Moutan Cortex Radicis inhibits the nigrostriatal damage in a 6-OHDA-induced Parkinson’s disease model.
COGNITION
–Resveratrol oligomers from Paeonia suffruticosa protect mice against cognitive dysfunction by regulating cholinergic, antioxidant and anti-inflammatory pathways.
–Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice.